Gregory O. Dussor

Prolactin Receptor Long Isoform ΔS1 Expression is Reduced in the Dorsal Root Ganglia of Humans with Chronic Pain

The paper examines PRLR isoform expression in human dorsal root ganglia, finding higher PRLR-L (ΔS1) expression in females and reduced expression in females with chronic pain.

History of opioid use disorder correlates with altered neuroimmune signatures in the human dorsal root ganglia

The paper examines molecular and physiological changes in dorsal root ganglia from individuals with and without opioid use disorder, identifying altered neuroimmune signatures and sensitized sensory neurons.

Chronic lower limb pain is not associated with a loss of inhibitory neurons in the human lumbar spinal dorsal horn

This study examines the anatomical changes in the human lumbar spinal dorsal horn in relation to chronic lower limb pain and finds no association with neuronal density or inhibitory neuron loss.

Antibiotics modulate activity of mouse and human dorsal root ganglia neurons

The paper shows that antibiotics like β-lactams, macrolides, and tetracyclines alter calcium flux in DRG neurons through mechanisms involving extracellular calcium, TRPA1, and mitochondrial ROS.

Progressive neurodegeneration in human dorsal root ganglion from diabetes to painful neuropathy

The paper investigates neurodegeneration in dorsal root ganglia across diabetes and diabetic painful neuropathy stages, identifying early molecular changes and highlighting the need for early intervention.

A molecular map of the human spinal dorsal and ventral horn defines arrangement of neuronal types and glial sex differences

The paper maps molecular features of human spinal cord dorsal and ventral horns, identifying neuronal types and sex-specific glial differences using single-nucleus sequencing and spatial transcriptomics.

Enabling wider access to human molecular neuroscience research in pain: A simple preservation method for human dorsal root ganglion neurons in Hibernate A media

This paper introduces a method to preserve human dorsal root ganglion neurons using Hibernate media, enabling easier access and transport for research.

Decreased KCC2 expression in the human spinal dorsal horn associated with chronic pain and long-term opioid use

Mycobacterium tuberculosis sulfolipid-1 (Sl-1) increases the excitability of mouse and human TRPV1-positive sensory neurons in a YM254890-reversible fashion

This study shows that Mycobacterium tuberculosis sulfolipid-1 (SL-1) increases TRPV1-positive sensory neuron excitability through Gq/11 pathway activation and intracellular Ca2+ release.

Profiling Human iPSC-Derived Sensory Neurons for Analgesic Drug Screening Using a Multi-Electrode Array

This paper develops a high-content screening platform using hiPSC-derived nociceptors on micro-electrode arrays to identify analgesic drugs with reliable assay performance and functional target validation.

Suzetrigine (VX-548) exhibits activity-dependent effects on human dorsal root ganglion neurons

This study examines suzetrigine's effects on human dorsal root ganglion neurons, showing it suppresses spontaneous pain-related discharges but requires longer exposure to affect evoked pain.

Expansion of OSMR expression and signaling in the human dorsal root ganglion links OSM to neuropathic pain

The paper shows OSM-OSMR signaling via MAPKs drives transcriptomic changes in human DRG linked to neuropathic pain.

Nageotte nodules in human DRG reveal neurodegeneration in painful diabetic neuropathy

The paper identifies Nageotte nodules in diabetic painful neuropathy DRGs, showing they contain dead neurons and are linked to pain and sensory loss.

Ephrin-B2 promotes nociceptive plasticity and hyperalgesic priming through EphB2-MNK-eIF4E signaling in both mice and humans

This study shows ephrin-B2 promotes nociceptive plasticity and hyperalgesic priming in mice and humans through MNK-eIF4E signaling in DRG neurons.

Protease-Activated Receptor 2 (PAR2) expressed in sensory neurons contributes to signs of pain and neuropathy in paclitaxel treated mice

This study shows that PAR2 in sensory neurons contributes to paclitaxel-induced pain and neuropathy in mice, and that targeting PAR2 can alleviate these symptoms.

NaV1.7 mRNA and protein expression in putative projection neurons of the human spinal dorsal horn

The paper reports the expression of NaV1.7 mRNA and protein in specific neurons of the human spinal dorsal horn and discusses its potential role in pain phenotypes and analgesic efficacy.

Fragile X Mental Retardation Protein (FMRP) expression in human nociceptor axons of the spinal dorsal horn-- Implications for RNA targeting and localized translation

The paper investigates FMRP expression in human nociceptor axons of the spinal dorsal horn, finding it colocalizes with pain-related markers and suggests a role in sex dimorphic chronic pain mechanisms.

Resveratrol increases tear production and spontaneous ocular pain after corneal abrasion in male, but not female, rats using a preclinical model of photorefractive keratectomy (PRK)

This study develops a preclinical PRK model in rats to evaluate resveratrol's effect on ocular pain and tear production, finding sex-specific outcomes.

A female-specific role for Calcitonin Gene-Related Peptide (CGRP) in rodent pain models

This study investigates the sex-specific role of CGRP in pain models, finding that CGRP promotes pain plasticity in female mice but has limited impact in males.

RNA Profiling of Neuropathic Pain-Associated Human DRGs Reveal Sex-differences in Neuro-immune Interactions Promoting Pain

The paper profiles RNA in human DRGs from neuropathic pain patients, identifying sex-specific gene expression differences and neuro-immune pathways associated with pain.

Transient receptor potential canonical 5 (TRPC5) mediates inflammatory mechanical pain

This study identifies TRPC5 as a mediator of inflammatory mechanical pain using knockout mice and pharmacological inhibitors, showing its role in pain behaviors induced by lysophosphatidylcholine.

Diversity of receptor expression in central and peripheral mouse neurons estimated from single cell RNA sequencing

The paper compares receptor expression diversity between central and peripheral mouse neurons using single-cell RNA sequencing and finds similar diversity overall, with exceptions in GPCRs and cytokine receptors.

Spatial transcriptomics reveals unique molecular fingerprints of human nociceptors

The paper uses spatial transcriptomics to characterize human sensory neurons, comparing them to mouse and non-human primate data to identify similarities and divergences in drug targets.

A role for protease activated receptor type 3 (PAR3) in nociception demonstrated through development of a novel peptide agonist

The paper develops a PAR3 agonist and shows it induces mechanical hypersensitivity in mice, suggesting PAR3's role in nociception and plasticity.

Sex differences in nociceptor translatomes contribute to divergent prostaglandin signaling in male and female mice

The paper identifies sex differences in nociceptor translatomes, revealing sex-specific prostaglandin signaling differences in male and female mice.

Neuroendocrine mechanisms governing sex-differences in chronic pain involve prolactin receptor sensory neuron signaling

This study identifies sex-specific neuroendocrine mechanisms in chronic pain, showing that prolactin receptor signaling in sensory neurons contributes to hyperalgesic priming in females but not males.

The cellular basis of protease activated receptor type 2 (PAR2) evoked mechanical and affective pain

This study identifies a specific subset of sensory neurons expressing PAR2 that mediate mechanical and affective pain behaviors, clarifying the cellular basis of PAR2-evoked pain.

A pharmacological interactome platform for discovery of pain mechanisms and targets

The paper creates interactome maps of ligand-receptor interactions between peripheral cell types and sensory neurons in mouse and human disease states, identifying potential therapeutic targets like EGFR.

Type I interferons act directly on nociceptors to produce pain sensitization: Implications for viral infection-induced pain

This study shows type I interferons act directly on nociceptors via MNK-eIF4E signaling to cause pain hypersensitivity in mice, linking viral infections to pain and neuropathies.

Transcriptomic analysis of native versus cultured human and mouse dorsal root ganglia focused on pharmacological targets

The paper compares transcriptomes of native and cultured human and mouse dorsal root ganglia, finding reduced neuronal gene expression in culture but presence of key pharmacological targets.