Runx1 and Runx2 act in concert to suppress Wnt/β-catenin-driven mammary tumourigenesis
Alessandra I. Riggio, Kerri Sweeney, Robin Shaw, Amy Lawlor, Adiba Khan, Nicola Ferrari, Jayanthi Anand, Laura CA Galbraith, Kathryn L. Gilroy, Courtney Bull, Alex L. Young, Dimitris Athineos, Holly Hall, Farah Naz Ghaffar, Mark Hughes, , Karen Blyth
This study shows that Runx1 and Runx2 suppress Wnt/β-catenin-driven mammary tumourigenesis, with combined loss leading to increased tumour development and oncogenic pathway activation.
British Journal of Cancer · May 7, 2026Peer-reviewedCancer Biology