MicroRNA-335-5p suppresses voltage-gated sodium channel expression and may be a target for seizure control
Mona Heiland, Niamh M. C. Connolly, Omar Mamad, Thanh Ngoc Nguyen, Jaideep Kesavan, Elena Langa, Kevin Fanning, Albert Sanfeliu, Yan Yan, Junyi Su, Morten Trillingsgaard Venø, Lara S. Costard, Valentin Neubert, Tobías Engel, Thomas D. M. Hill, , David Clifford Henshall
This study identifies miR-335-5p as a regulator of voltage-gated sodium channels, showing that its modulation can influence seizure activity in epilepsy models.
Proceedings of the National Academy of Sciences · Jul 18, 2023Peer-reviewedNeuroscience