Yan Yan

Recipient cell identity governs intracellular transport and membrane interactions of extracellular vesicles across species

This study investigates how recipient cell identity influences intracellular transport and membrane interactions of extracellular vesicles across species, finding that recipient-cell environment has a greater impact than EV origin.

Native extracellular vesicles display surface bound RNAs that are co-delivered to cells

The paper identifies surface-bound RNA on extracellular vesicles and shows it is co-delivered to target cells, suggesting a new RNA uptake mechanism.

Extracellular vesicles from morphine-exposed prefrontal cortex carry transcriptomic and proteomic signatures of synaptic dysfunction

This study shows that chronic morphine exposure alters the transcriptomic and proteomic content of brain-derived extracellular vesicles from the prefrontal cortex, which can reprogram recipient neurons.

Snorkel-tag Based Affinity Chromatography for Recombinant Extracellular Vesicle Purification

This paper introduces a Snorkel-tag system for affinity purification of extracellular vesicles using CD81 fused with tags and transmembrane domains, enabling non-destructive isolation and future applications in tracing and analyzing EVs.

Brain cell-specific origin of circulating microRNA biomarkers in experimental temporal lobe epilepsy

The paper identifies brain-originating microRNAs in the blood of mice with experimental epilepsy, supporting their use as biomarkers.

MicroRNA-335-5p suppresses voltage-gated sodium channel expression and may be a target for seizure control

This study identifies miR-335-5p as a regulator of voltage-gated sodium channels, showing that its modulation can influence seizure activity in epilepsy models.

A systems approach delivers a functional microRNA catalog and expanded targets for seizure suppression in temporal lobe epilepsy

The paper identifies functional miRNAs and their targets involved in seizure suppression in temporal lobe epilepsy using animal models and functional screens.