Tobías Engel

This study shows that P2X7R antagonists enhance the effectiveness of anti-seizure medications in human epileptic brain tissue by reducing inflammation and improving drug response.

The paper compares miRNA profiles across HT22, N2A, SH-SY5Y cell lines and primary mouse hippocampal neurons to assess their similarity to primary neurons.

This study identifies miR-335-5p as a regulator of voltage-gated sodium channels, showing that its modulation can influence seizure activity in epilepsy models.

This study shows that immunoproteasome deficiency accelerates brain aging and causes epilepsy in mice, with reduced immunoproteasome expression also observed in human epilepsy patients.

This study shows that deleting miR-155 in myeloid cells reduces seizure severity and inflammation in a neonatal hypoxia-induced seizures model.

This study demonstrates functional P2X7R expression in human iPSC-derived neurons and astrocytes using calcium imaging and immunostaining.

The paper compares gene expression in a mouse model of status epilepticus to human temporal lobe epilepsy tissue, finding high concordance in gene dysregulation and shared molecular features.

The paper identifies functional miRNAs and their targets involved in seizure suppression in temporal lobe epilepsy using animal models and functional screens.

This study identifies widespread changes in mRNA polyadenylation in temporal lobe epilepsy, highlighting the role of CPEB4 in seizure severity and neurodegeneration.