Dietary control of peripheral adipose storage capacity through membrane lipid remodelling
Marc J. P. M. Tol, Yuta Shimanaka, Alexander H. Bedard, Jennifer L. Sapia, Liujuan Cui, Mariana Colaço-Gaspar, Peter Hofer, Alessandra Ferrari, Kevin Qian, John Paul Kennelly, Stephen D. Lee, Yajing Gao, Xiao Xu, Jie Gao, Julia J. Mack, , Peter Tontonoz
This study shows that PPARγ controls adipose tissue expansion by regulating LPCAT3, which affects membrane lipid composition and triglyceride storage, linking dietary n-6 PUFAs to energy balance.
Nature Metabolism · Jun 27, 2025Peer-reviewedPhysiology