Julia J. Mack

Skin capillary endothelial cells form a network of spatiotemporally conserved Ca2+ activity

The paper uses intravital imaging to study Ca2+ activity in skin capillaries of live mice, revealing spatiotemporal organization and regulation through gap junctions and L-type Ca2+ channels.

Lipid- and protein-directed photosensitizer proximity labeling captures the cholesterol interactome

This paper introduces POCA, a photosensitizer-based proximity labeling method that captures both protein and lipid interactomes with high spatiotemporal resolution.

Dietary control of peripheral adipose storage capacity through membrane lipid remodelling

This study shows that PPARγ controls adipose tissue expansion by regulating LPCAT3, which affects membrane lipid composition and triglyceride storage, linking dietary n-6 PUFAs to energy balance.

Cholesterol binding to VCAM-1 promotes vascular inflammation

The paper identifies cholesterol binding to VCAM-1 as a mechanism promoting vascular inflammation by stabilizing VCAM-1 and enhancing immune cell recruitment.

Flow-Mediated Modulation of the Endothelial Cell Lipidome

This study examines how different blood flow patterns alter the lipidome of human aortic endothelial cells and identifies stimulus-specific lipid reprogramming in response to pro-inflammatory agonists.

Vascular Injury Changes Topology of Vessel Network to Adapt to Partition of Blood Flow for New Arteriovenous Specification

The paper shows that vascular injury leads to changes in vessel network topology to increase blood flow and activate Notch-ephrinb2 signaling for microcirculation restoration.