Disruption of a Hedgehog-Foxf1-Rspo2 Signaling Axis Leads to Tracheomalacia and a Loss of Sox9+ Tracheal Chondrocytes
Talia Nasr, Andrea M. Holderbaum, Praneet Chaturvedi, Kunal Agarwal, Jessica L. Kinney, Keziah Daniels, Stephen L. Trisno, Vladimir Ustiyan, John M. Shannon, James M. Wells, Debora I. Sinner, Vladimir V. Kalinichenko, Aaron M. Zorn
This study identifies a HH-Foxf1-Rspo2 signaling axis critical for tracheal cartilage development and shows its disruption leads to tracheomalacia.
Disease Models & Mechanisms · Dec 16, 2020Peer-reviewedDevelopmental Biology