Sirtuin2 blockade inhibits replication of Human Immunodeficiency Virus-1 and 1 Mycobacterium tuberculosis in macrophages and humanized mice
Vipul Kumar Singh, Abhishek Mishra, Khanghy Truong, José Alejandro Bohórquez, Suman Sharma, Arshad Khan, Franz Bracher, Kangling L Zhang, Janice Jones Endsley, Mark A. Endsley, Andrew P. Rice, Jason T. Kimata, Guohua Yi, Chinnaswamy Jagannath
This study shows that Sirt2 inhibition reduces HIV-1 and Mtb replication in macrophages and humanized mice, suggesting a dual therapeutic strategy.
Molecular Therapy · Mar 25, 2026Peer-reviewedImmunology