Author

Chinnaswamy Jagannath

Houston Methodist Research InstituteORCID 0000-0002-3014-2857Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Research Focus:host-pathogen & immune response· 2 Research Focus:cell type annotation· 1 Research Focus:development & morphogenesis· 1 Research Focus:drug response / drug discovery· 1 Organism:human· 1 Research Focus:metabolism & bioenergetics· 1 Assay:metagenomics· 1

Frequent Co-Authors

Guohua YiiD· 2 shared José Alejandro BohórqueziD· 2 shared Abhishek MishraiD· 1 shared Andrew P. RiceiD· 1 shared Arshad Khan· 1 shared Danish Ansari· 1 shared Franz BracheriD· 1 shared Gaurav Singh· 1 shared

Activity by Year

2024-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 33 mutual co-author links

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2 shared papersImmunology

Guohua YiORCID

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2 papers

Recent·Most cited

Sirtuin2 blockade inhibits replication of Human Immunodeficiency Virus-1 and 1 Mycobacterium tuberculosis in macrophages and humanized mice

Vipul Kumar Singh, Abhishek Mishra, Khanghy Truong, José Alejandro Bohórquez, Suman Sharma, Arshad Khan, Franz Bracher, Kangling L Zhang, Janice Jones Endsley, Mark A. Endsley, Andrew P. Rice, Jason T. Kimata, Guohua Yi, Chinnaswamy Jagannath

This study shows that Sirt2 inhibition reduces HIV-1 and Mtb replication in macrophages and humanized mice, suggesting a dual therapeutic strategy.

Molecular Therapy · Mar 25, 2026Peer-reviewedImmunology

A Novel Humanized Mouse Model for HIV and Tuberculosis Co-infection Studies

José Alejandro Bohórquez, Sitaramaraju Adduri, Danish Ansari, Sahana John, Jon Florence, Omoyeni Adejare, Gaurav Singh, Nagarjun Venkata Konduru, Chinnaswamy Jagannath, Guohua Yi

This study develops a humanized mouse model to study HIV and tuberculosis co-infection, showing it recapitulates human immune, pathological, and metabolic responses.

Frontiers in Immunology · May 10, 2024Peer-reviewedImmunology