Restraining Wnt activation and intestinal tumorigenesis by a Rab35 dependent GTPase relay
Siamak Redhai, Tianyu Wang, Kim. E Boonekamp, Saskia Reuter, Tümay Capraz, Svenja Leible, Shivohum Bahaguna, Fillip Port, Bojana Pavlović, Michaela Holzem, Roman M. Doll, Niklas Rindtorff, Erica Valentini, Barbara Schmitt, Karsten Richter, , Michael Boutros
This study identifies Rab35 as a tumor suppressor that modulates Wnt signaling through a GTPase relay, highlighting its role in restraining intestinal tumorigenesis.
bioRxiv · Feb 5, 2024 · PreprintCancer Biology