Michaela Holzem

Proliferation and differentiation of intestinal stem cells depends on the zinc finger transcription factor BCL11/Chronophage

This study identifies Cph as a key regulator of intestinal stem cell proliferation and differentiation, showing its role in maintaining ISC and EE populations and remodeling progenitor transcriptomes.

Direct detection of CRISPR mutations and transcriptional responses at single cell resolution in vivo

This paper introduces scPT-seq, a method to detect CRISPR mutations and transcriptional responses at single-cell resolution in vivo, revealing clonal markers and lineage dynamics in Drosophila intestine.

Class III PI3K is essential for Wingless secretion and Evi/Wls recycling in Drosophila

The paper identifies Vps15 as essential for endocytosis-dependent Wg secretion and reveals divergent post-endocytic fates of Wg and Evi/Wls in Drosophila.

Restraining Wnt activation and intestinal tumorigenesis by a Rab35 dependent GTPase relay

This study identifies Rab35 as a tumor suppressor that modulates Wnt signaling through a GTPase relay, highlighting its role in restraining intestinal tumorigenesis.

Widespread retention of ohnologs in key developmental gene families following whole genome duplication in arachnopulmonates

The paper examines retention of ohnologs in developmental gene families across arachnopulmonate species, finding extensive retention and evolutionary patterns in Hox, Wnt, and frizzled genes.