Author

Svenja Leible

German Cancer Research Center

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Developmental Biology· 2 Genetics· 1 Genomics· 1 Molecular Biology· 1

Signature Assays, Organisms & Methods

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Organism:Drosophila· 4 Assay:scRNA-seq· 4 Research Focus:cell type annotation· 3 Approach:experimental assay· 3 Research Focus:differential expression· 2 Research Focus:gene regulatory network inference· 2 Approach:statistical model· 2 Research Focus:benchmarking· 1

Frequent Co-Authors

Michael BoutrosiD· 5 shared Erica ValentiniiD· 3 shared Aurelio A. TelemaniD· 2 shared Josephine BageritziD· 2 shared Michaela HolzemiD· 2 shared Siamak RedhaiiD· 2 shared Tianyu WangiD· 2 shared Christina KoiD· 1 shared

Activity by Year

2017-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 33 mutual co-author links

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5 shared papersDevelopmental Biology

Michael BoutrosORCID

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5 papers

Recent·Most cited

Proliferation and differentiation of intestinal stem cells depends on the zinc finger transcription factor BCL11/Chronophage

Siamak Redhai, Nick Hirschmüller, Tianyu Wang, Tyler Jackson, Stefan Peidli, Erica Valentini, Shivohum Bahuguna, Svenja Leible, Sarina Möller, Christina Ko, Michaela Holzem, Sviatoslav Kharuk, Lea Bräckow, Fillip Port, David Ibberson, , Michael Boutros

This study identifies Cph as a key regulator of intestinal stem cell proliferation and differentiation, showing its role in maintaining ISC and EE populations and remodeling progenitor transcriptomes.

The EMBO Journal · May 20, 2026Peer-reviewedDevelopmental Biology

Direct detection of CRISPR mutations and transcriptional responses at single cell resolution in vivo

John A. Hawkins, Siamak Redhai, Svenja Leible, Mireia Osuna Lopez, Hilal Ozgur, Tianyu Wang, Michaela Holzem, Michael Boutros, Oliver Stegle

This paper introduces scPT-seq, a method to detect CRISPR mutations and transcriptional responses at single-cell resolution in vivo, revealing clonal markers and lineage dynamics in Drosophila intestine.

bioRxiv · Dec 24, 2025 · PreprintMolecular Biology

Glyoxal as alternative fixative for single cell RNA sequencing

Josephine Bageritz, Niklas Krausse, Schayan Yousefian, Svenja Leible, Erica Valentini, Michael Boutros

This study develops and benchmarks glyoxal as a fixative for scRNA-seq, showing it preserves transcriptomes in Drosophila and human cells with high correlation to unfixed samples.

G3 Genes Genomes Genetics · Jul 26, 2023Peer-reviewedGenomics

Gene expression atlas of a developing tissue by single cell expression correlation analysis

Josephine Bageritz, Philipp Willnow, Erica Valentini, Svenja Leible, Michael Boutros, Aurelio A. Teleman

The paper develops a new method for analyzing scRNA-seq data based on gene expression correlations to generate a gene expression atlas of the Drosophila wing disc, identifying 824 genes with spatially restricted expression patterns.

Nature Methods · Jul 29, 2019Peer-reviewedDevelopmental Biology

Sorting & Sequencing Flies By Size: Identification Of Novel TOR Regulators And Parameters For Successful Sorting

Katrin Straßburger, Tanja Zöller, Thomas Sandmann, Svenja Leible, Gráinne Kerr, Michael Boutros, Aurelio A. Teleman

The paper describes a sort-and-sequence experiment to identify TOR regulators by selecting flies for wing length, finding novel regulators and parameters to improve experimental reliability.

bioRxiv · Mar 24, 2017 · PreprintGenetics