Fragility of ER homeostatic regulation underlies haploid instability in human somatic cells
Sumire Ishida‐Ishihara, Kan Yaguchi, Sena Miura, Ryoto Nomura, QiJiao Wang, Koya Yoshizawa, Kimino Sato, Guang Yang, Krisztina Veszelyi, Gábor Bánhegyi, Éva Margittai, Ryota Uehara
This study identifies ER stress-induced proteotoxicity as a key factor causing haploid instability in human somatic cells, showing that haploids are more prone to apoptosis due to inefficient proteostasis.
Journal of Biological Chemistry · Oct 19, 2024Peer-reviewedBiochemistry