BiochemistryJournal of Biological ChemistryPeer-reviewed
Fragility of ER homeostatic regulation underlies haploid instability in human somatic cells
Sumire Ishida‐Ishihara, Kan Yaguchi, Sena Miura…·Ryota Uehara
This study identifies ER stress-induced proteotoxicity as a key factor causing haploid instability in human somatic cells, showing that haploids are more prone to apoptosis due to inefficient proteostasis.
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