Kan Yaguchi

Spindle pole proteins confine chromosomes to ensure their expulsion during female meiosis

The paper identifies ZYG-9/ch-TOG as a spindle pole protein that binds DNA and packages meiotic chromosomes into polar bodies, ensuring proper genome copy number in oocytes.

TRIM37 recognizes a bipartite degron to ubiquitinate centrosome substrates

The paper identifies a bipartite degron in Cep192 that allows TRIM37 to ubiquitinate and regulate centrosome proteins.

The condensate-forming protein eIF4ET ensures adequate levels of meiotic proteins to support oocyte storage

This study identifies eIF4ET's role in maintaining oocyte proteome stability during long-term storage by forming condensates, with implications for age-related infertility.

Haploidy-linked cell proliferation defects limit larval growth in Zebrafish

This study identifies mitotic defects and cell death in haploid zebrafish larvae as key factors limiting larval growth, revealing a conserved cellular mechanism across vertebrates.