Koya Yoshizawa

This study identifies Cep192 insufficiency as a cause of haploid instability in human cells and shows that restoring Cep192 or enhancing the acentrosomal spindle pathway stabilizes haploid cells.

This study identifies ER stress-induced proteotoxicity as a key factor causing haploid instability in human somatic cells, showing that haploids are more prone to apoptosis due to inefficient proteostasis.