Low-affinity ligands of the epidermal growth factor receptor are long-range signal transmitters during collective cell migration of epithelial cells
Eriko Deguchi, Shuhao Lin, Daiki Hirayama, Kimiya Matsuda, Akira Tanave, Kenta Sumiyama, Shinya Tsukiji, Tetsuhisa Otani, Mikio Furuse, Alexander D. Sorkin, Michiyuki Matsuda, Kenta Terai
This study shows low-affinity EGFRLs like EREG and AREG transmit signals more efficiently than high-affinity ligands during collective cell migration and wound healing.
Cell Reports · Nov 1, 2024Peer-reviewedCell Biology