Shinya Tsukiji

De novo chemo-optogenetics through rational small-molecule design and TRAP display

This paper introduces a method to create synthetic chemo-optogenetic tools by combining rational small-molecule design with TRAP display to generate light-controlled protein binders.

Low-affinity ligands of the epidermal growth factor receptor are long-range signal transmitters during collective cell migration of epithelial cells

This study shows low-affinity EGFRLs like EREG and AREG transmit signals more efficiently than high-affinity ligands during collective cell migration and wound healing.

Chemogenetic manipulation of endogenous proteins in fission yeast using a self-localizing ligand-induced protein translocation (SLIPT) system

This study applies the SLIPT system to fission yeast to perturb cell cycle-related proteins with improved temporal resolution.

Synthetic protein condensates that recruit and release protein activity in living cells

This paper develops synthetic protein condensates that can recruit or release protein activity in mammalian cells using small molecules or light.

A chemogenetic platform for controlling plasma membrane signaling and synthetic signal oscillation

This paper introduces a chemogenetic platform that enables rapid, reversible, and repeatable control of plasma membrane protein translocation using a novel engineered tag and ligand pair.