Michiyuki Matsuda

The slow-acting G-protein Gz defines the duration of circadian rest time

This study shows that Gz G-protein regulates the duration of circadian rest time by modulating cAMP-PKA activity and transcriptome remodeling in the SCN.

Intensity Modulation of Trichromatic Split Fluorescent Proteins for Live Cell Mapping

The paper introduces Caterpie, a live cell labeling system using split fluorescent proteins to enable high-fidelity identification of multiple cell populations with 97% accuracy.

E-cadherin mechanotransduction activates EGFR-ERK signaling in epithelial cells by inducing ADAM-mediated ligand shedding

This study shows mechanical strain activates EGFR-ERK signaling in epithelial cells via E-cadherin-induced ADAM17-mediated ligand shedding.

Low-affinity ligands of the epidermal growth factor receptor are long-range signal transmitters during collective cell migration of epithelial cells

This study shows low-affinity EGFRLs like EREG and AREG transmit signals more efficiently than high-affinity ligands during collective cell migration and wound healing.

ERK-mediated Curvature Feedback Regulates Branching Morphogenesis in Lung Epithelial Tissue

The paper shows ERK-mediated curvature feedback regulates branching morphogenesis in murine lung epithelial tissue through a negative feedback loop.

Incoherent feedforward regulation via Sox9 and Erk underpins mouse tracheal cartilage development

The paper identifies an incoherent feedforward loop between Sox9 and Erk that regulates tracheal cartilage development in mice.

Interplay between medial nuclear stalling and lateral cellular flow underlies cochlear duct morphogenesis

The paper investigates the mechanisms of cochlear duct morphogenesis by analyzing cellular dynamics and signaling patterns during development.