Tetsuhisa Otani

The paper uses expansion microscopy to show that epithelial cell density changes the organization of desmoplakin in junctions, with increased C-terminal spacing in confluent monolayers.

This study shows ZO-1 moves between tight junctions and podosomes during collective cell migration, regulated by ERK activity, and contributes to cell adhesion and movement.

The paper reconstitutes planar cell polarity in cultured epithelial cells by integrating Wnt signaling, tissue tension, and Prickle3 overexpression, showing their roles in polarity axis establishment and direction.

This study shows that afadin's multivalent interactions drive IDR-mediated condensate formation, promoting AJC formation and junctional separation in epithelial cells.

The paper evaluates mechanical features of cell-cell interactions by relating effective pairwise forces to sub-cellular components using vertex model data.

The paper shows that ZO-1/ZO-2-deficient cells are selectively eliminated by cell competition, mediated by supracellular actomyosin cables and Hippo signaling, to maintain epithelial barrier homeostasis.

This study shows low-affinity EGFRLs like EREG and AREG transmit signals more efficiently than high-affinity ligands during collective cell migration and wound healing.