Positioning of nucleosomes containing γ-H2AXprecedes active DNA demethylation and transcription initiation
Stephanie Dobersch, Karla Rubio, Indrabahadur Singh, Stefan Günther, Johannes Graumann, Julio Cordero, Rafael Castillo‐Negrete, Minh Bao Huynh, Aditi Mehta, Peter Braubach, Héctor A. Cabrera-Fuentes, Jürgen Bernhagen, Cho‐Ming Chao, Savério Bellusci, Andreas Günther, , Guillermo Barreto
The paper shows that HMGA2 induces DNA nicks required for nucleosome incorporation containing H2A.X, which is necessary for DNA demethylation and transcription initiation.
Nature Communications · Feb 16, 2021Peer-reviewedMolecular Biology