Karla Rubio

Cell-specific FUS loss enhances ageing-associated transcriptional elongation in lung fibrosis

The paper investigates how FUS loss in fibroblasts affects transcriptional elongation and senescence in IPF, finding that reduced FUS levels increase Pol II activity and fibrosis-related gene expression.

3D genome organization during TGFB-induced transcription requires nuclear microRNA and G-quadruplexes

The paper shows that nuclear miR-9 is required for chromatin features and promoter-super-enhancer looping during TGFB1-induced transcriptional activation.

DrugMap: A quantitative pan-cancer analysis of cysteine ligandability

DrugMap quantitatively analyzes cysteine ligandability across 416 cancer cell lines, revealing redox state, conformational changes, and mutations as drivers of variability, and identifies covalent inhibitors targeting NFκB1 and SOX10.

Positioning of nucleosomes containing γ-H2AXprecedes active DNA demethylation and transcription initiation

The paper shows that HMGA2 induces DNA nicks required for nucleosome incorporation containing H2A.X, which is necessary for DNA demethylation and transcription initiation.