Peter Braubach

The paper investigates how FUS loss in fibroblasts affects transcriptional elongation and senescence in IPF, finding that reduced FUS levels increase Pol II activity and fibrosis-related gene expression.

This paper presents the first single-nucleus RNA sequencing atlas of pleuroparenchymal fibroelastosis, identifying novel cell states and their spatial organization in lung fibrosis.

This paper identifies Trypstatin, a Kunitz-type protease inhibitor that inhibits TMPRSS2 and related proteases, showing broad-spectrum antiviral activity against SARS-CoV-2, influenza, and other respiratory viruses.

The paper shows that HMGA2 induces DNA nicks required for nucleosome incorporation containing H2A.X, which is necessary for DNA demethylation and transcription initiation.