A genome-wide CRISPR activation map of surface protein expression in human CD4 T cells
Yutong V Wang, Junha Park, Min Cheol Kim, Thomas Mazumder, Krishna Sonpal, Matin Bikaran, Zachary Steinhart, Ralf L. J. Schmidt, Yang Sun, Su-Hyeon Lee, Alexander Marson, Chun Ye, Byungjin Hwang
This paper introduces SCITO-Perturb-seq, a CRISPRa platform that maps surface protein regulation in CD4 T cells, finding 16% of activated genes alter surface protein expression.
bioRxiv · Aug 11, 2026 · PreprintGenomics