Author

Kristian Lorenzo

Jackson Laboratory

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Genetics· 1 Immunology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Organism:mouse· 2 Assay:bulk RNA-seq· 1 Research Focus:host-pathogen & immune response· 1 Assay:proteomics· 1

Frequent Co-Authors

Vishnu HosuriD· 2 shared Basile TarchiniiD· 1 shared Ellen I. HartigiD· 1 shared Hannah R. MegathliniD· 1 shared Jing WeniD· 1 shared Lauren Togonon Arayan· 1 shared Leonard D. ShultziD· 1 shared Lisa M. BurzenskiiD· 1 shared

Activity by Year

2025-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 25 mutual co-author links

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2 shared papersImmunology

Vishnu HosurORCID

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2 papers

Recent·Most cited

Redundant γc cytokines license IL-1-driven neutrophil inflammation through MEK/ERK convergence

Kristian Lorenzo, Lauren Togonon Arayan, Timothy M. Stearns, Lisa M. Burzenski, Jing Wen, Leonard D. Shultz, Vishnu Hosur

This study identifies redundant γc cytokines that enhance IL-1-driven neutrophil inflammation via MEK/ERK convergence, showing that blocking the shared γc receptor or MEK/ERK reduces disease severity.

bioRxiv · Jun 1, 2026 · PreprintImmunology

Large-Scale Genome-Wide Optimization and Prediction of the Cre Recombinase System for Precise Genome Manipulation in Mice

Valerie Erhardt, Ellen I. Hartig, Kristian Lorenzo, Hannah R. Megathlin, Basile Tarchini, Vishnu Hosur

This study optimizes the Cre-Lox system for efficient genome modification in mice by analyzing factors like loxP distance, Cre-driver strain, and breeding age.

Genome biology · Apr 4, 2025Peer-reviewedGenetics