Ellen I. Hartig

This study optimizes the Cre-Lox system for efficient genome modification in mice by analyzing factors like loxP distance, Cre-driver strain, and breeding age.

The paper shows genetic variation in mouse ESCs affects lineage commitment by modulating pluripotency epigenome regulators, with B6 and D2 strains showing distinct differentiation biases.

The paper investigates the long-term effects of chronic cortisol exposure during zebrafish embryonic development, finding persistent neuroendocrine dysregulation and altered gene expression in adulthood.

The paper identifies Klf9 as a key regulator of the transcriptomic response to glucocorticoid receptor activity in zebrafish larvae, showing it mediates proinflammatory gene upregulation under chronic cortisol exposure.