Kristin M. Perkumas

The paper uses single-cell RNA sequencing to identify age-related immune remodeling in ocular outflow tissues that may help maintain intraocular pressure.

This study shows that microtubule stability affects Schlemm's canal cell mechanics and outflow facility in glaucoma by altering contractility, stiffness, and pore formation.

This study identifies glucocorticoid-induced transcriptomic changes in human trabecular meshwork and Schlemm's canal cells using RNA-seq, finding genes associated with glaucoma and intraocular pressure.

This study shows that endothelial cell stiffness and type influence biomechanically-induced transcellular pore formation in Schlemms canal cells.

This study shows TRPV4 modulates substrate stiffness sensing and transcellular pore formation in Schlemm's canal cells, with implications for glaucoma treatment.