Uncovering the dark transcriptome in polarized neuronal compartments with mcDETECT
Chenyang Yuan, Krupa Patel, Hongshun Shi, Hsiao‐Lin V. Wang, Feng Wang, Rong-Hua Li, Yangping Li, Victor G. Corces, Hailing Shi, Sulagna Das, Jindan Yu, Peng Jin, Bing Yao, Jian Hu
The paper introduces mcDETECT, a machine learning framework for detecting RNA granules in spatial transcriptomics data, revealing functionally distinct neuronal substates and early Alzheimer's disease pathology.
bioRxiv · Mar 27, 2025 · PreprintBioinformatics