Bing Yao

Temporal RNA splicing dysregulation in a human multicellular model of C9orf72 ALS

This study uses human spinal cord organoids to model C9orf72 ALS, identifying early RNA splicing dysregulation and RBP network dysfunction as key features of the disease.

HELZ is a RNA-DNA helicase that resolves R loops to facilitate homologous recombination repair

This study identifies HELZ as an RNA-DNA helicase that resolves R loops to support homologous recombination repair and genomic stability.

MorphLink: Bridging Cell Morphological Behaviors and Molecular Dynamics in Multi-modal Spatial Omics

MorphLink identifies disease-related morphological-molecular interplays in multi-modal spatial omics data by linking interpretable morphological features with molecular measurements.

Uncovering the dark transcriptome in polarized neuronal compartments with mcDETECT

The paper introduces mcDETECT, a machine learning framework for detecting RNA granules in spatial transcriptomics data, revealing functionally distinct neuronal substates and early Alzheimer's disease pathology.