Sulagna Das

An integrated RNA-centric imaging and omics approach reveals distinct properties and composition of neuronal RNA granules

The paper uses integrated imaging and omics approaches to show that Actb and Arc mRNAs are packaged into distinct granules with different trafficking dynamics and functional roles.

Single-molecule imaging reveals activity-dependent regulation of Camk2a mRNAs at dendritic spines

The paper uses single-molecule imaging to show activity-dependent localization and translation of Camk2a mRNA at dendritic spines, revealing a mechanism for maintaining CaMKII levels during synaptic plasticity.

Uncovering the dark transcriptome in polarized neuronal compartments with mcDETECT

The paper introduces mcDETECT, a machine learning framework for detecting RNA granules in spatial transcriptomics data, revealing functionally distinct neuronal substates and early Alzheimer's disease pathology.

Ribosome-Associated Vesicles promote activity-dependent local translation in neurons

The paper identifies Ribosome-Associated Vesicles (RAVs) as dynamic platforms that facilitate activity-dependent local translation in neurons by transporting ribosomes to distal processes.

Real-time imaging of Arc/Arg3.1 transcription ex vivo reveals input-specific immediate early gene dynamics

This study uses real-time imaging to show that Arc/Arg3.1 transcription in neurons varies based on the type of synaptic input, revealing distinct dynamics for medial and lateral perforant path activation.

Cycles of transcription and local translation support molecular long-term memory in the hippocampus

The paper investigates how transcription and translation cycles of the IEG Arc support long-term memory in the hippocampus by maintaining mRNA supply to dendrites.