Microbiome-host interactions drive a trade-off between sleep quality and lifespan in Drosophila
Priyanshu Bhargava, Shenyue Chen, Jinho Lee, Yuto Yoshinari, Takashi Nishimura, Masayuki Ushio, Yuki Sugiura, Kwun For Cheng, Yu Shan Fung, Koji Hase, Hugh Nakamura, Masato Enomoto, Jung Kim, Heath E. Johnson, Yi Hung Liao, Yukinori Hirano
This study shows that microbiome-host interactions in Drosophila create a trade-off between sleep quality and lifespan through specific bacterial metabolites and host responses.
bioRxiv · Dec 26, 2025 · PreprintAnimal Behavior & Cognition