Author

L. A. Freeman

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biochemistry· 1 Cell Biology· 1

Signature Assays, Organisms & Methods

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Research Focus:differential expression· 1 Approach:experimental assay· 1 Research Focus:gene regulatory network inference· 1 Approach:genetic perturbation / CRISPR· 1 Organism:human· 1 Research Focus:protein folding & dynamics· 1 Assay:structural biology· 1 Research Focus:variant effect prediction· 1

Frequent Co-Authors

A. T. Remaley· 2 shared A. Glukhova· 1 shared A. Jadhav· 1 shared A. Schwendeman· 1 shared A. T. Bansal· 1 shared B. Baljinnyam· 1 shared B. Vaisman· 1 shared C. A. Combs· 1 shared

Activity by Year

2018-2020 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 25 mutual co-author links

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2 shared papersCell Biology

A. T. Remaley

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Author profile →

2 papers

Recent·Most cited

Transgelin: A New Gene Involved in LDL Endocytosis Identified by a Genome-wide CRISPR-Cas9 Screen

D. Lucero, O. Dikilitas, M. M. Mendelson, P. Islam, E. B. Neufeld, A. T. Bansal, L. A. Freeman, B. Vaisman, J. Tang, C. A. Combs, Y. Li, S. Voros, I. J. Kullo, A. T. Remaley

This study identifies TAGLN as a new gene involved in LDL endocytosis through a CRISPR-Cas9 screen and shows its association with plasma lipid levels.

bioRxiv · Dec 23, 2020Cell Biology

Molecular basis for activation of lecithin:cholesterol acyltransferase by a compound that increases HDL cholesterol

K. A. Manthei, S.-M. Yang, B. Baljinnyam, L. Chang, A. Glukhova, W. Yuan, L. A. Freeman, D. J. Maloney, A. Schwendeman, A. T. Remaley, A. Jadhav, J. J. G. Tesmer

The paper reports the crystal structure of LCAT bound to an activator and inhibitor, showing how the activator stabilizes the MBD and enhances LCAT activity in FLD variants.

bioRxiv · Sep 20, 2018Biochemistry