Author

S.-M. Yang

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Pharmacology & Toxicology· 2 Biochemistry· 1 Cancer Biology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 4 Research Focus:host-pathogen & immune response· 2 Research Focus:cancer & tumor microenvironment· 1 Research Focus:cell signaling & trafficking· 1 Assay:clinical cohort / trial· 1 Research Focus:differential expression· 1 Organism:human· 1 Organism:mouse· 1

Frequent Co-Authors

D. J. Maloney· 2 shared A. Glukhova· 1 shared A. Jadhav· 1 shared A. Schwendeman· 1 shared A. T. Remaley· 1 shared B. Baljinnyam· 1 shared B. Tang· 1 shared D.-M. Zhang· 1 shared

Activity by Year

2018-2020 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 22 mutual co-author links

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Curved chords = mutual co-authorship

2 shared papersPharmacology & Toxicology

D. J. Maloney

Mutual co-authors in cluster

Author profile →

4 papers

Recent·Most cited

Discovery of rhodomyrtone as a broad-spectrum antiviral inhibitor with anti-SARS-CoV-2 activity

W. Tang, J. Lu, Q.-Y. Song, M.-M. Li, L.-F. Chen, L.-J. Hu, S.-M. Yang, D.-M. Zhang, Y. Wang, Y.-L. Li, W.-C. Ye

This paper identifies rhodomyrtone as a broad-spectrum antiviral with activity against SARS-CoV-2 and other viruses, showing potent antiviral effects and low resistance potential.

bioRxiv · Nov 14, 2020 · PreprintPharmacology & Toxicology

Ameliorative effect of a quinazoline-based bromodomain inhibitor, CN210, on experimentally-induced Crohn's disease-like murine ileitis via inhibition of inflammatory cytokine expression

T. Noguchi, K. Hidaka, S. Kobayashi, K. Matsumoto, M. Yoshioka, S.-M. Yang, D. J. Maloney, S. Kato

This study shows that CN210, a quinazoline-based BET inhibitor, reduces inflammation in a murine model of Crohn's disease by inhibiting inflammatory cytokine expression and NF-κB/MAP kinase pathways.

bioRxiv · Jan 24, 2020Pharmacology & Toxicology

Molecular basis for activation of lecithin:cholesterol acyltransferase by a compound that increases HDL cholesterol

K. A. Manthei, S.-M. Yang, B. Baljinnyam, L. Chang, A. Glukhova, W. Yuan, L. A. Freeman, D. J. Maloney, A. Schwendeman, A. T. Remaley, A. Jadhav, J. J. G. Tesmer

The paper reports the crystal structure of LCAT bound to an activator and inhibitor, showing how the activator stabilizes the MBD and enhances LCAT activity in FLD variants.

bioRxiv · Sep 20, 2018Biochemistry

VPAC1 couples with TRPV4 channel to promote calcium-dependent gastric cancer progression

B. Tang, J. Wu, M. X. Zhu, X. Sun, J. Liu, R. Xie, T. X. Dong, Y. Xiao, J. M. Carethers, S.-M. Yang, H. Dong

This study shows that VPAC1 and TRPV4 channel interaction promotes calcium-dependent gastric cancer progression through a positive feedback loop involving VIP secretion.

bioRxiv · Jul 2, 2018Cancer Biology