Author

A. T. Remaley

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Immunology· 2 Biochemistry· 1 Biophysics· 1 Cell Biology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 4 Research Focus:cell type annotation· 1 Research Focus:differential expression· 1 Research Focus:drug response / drug discovery· 1 Research Focus:gene regulatory network inference· 1 Approach:genetic perturbation / CRISPR· 1 Organism:human· 1 Organism:mouse· 1

Frequent Co-Authors

A. Fowler· 2 shared B. Chackerian· 2 shared L. A. Freeman· 2 shared M. Sampson· 2 shared A. Glukhova· 1 shared A. Jadhav· 1 shared A. Schwendeman· 1 shared A. T. Bansal· 1 shared

Activity by Year

2018-2023 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 14 mutual co-author links

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2 shared papersImmunology

A. Fowler

Mutual co-authors in cluster

Author profile →

5 papers

Recent·Most cited

Structural flexibility of apolipoprotein E-derived arginine-rich peptides improves their cell penetration capability

Y. Takechi-Haraya, T. Ohgita, A. Usui, K. Nishitsuji, K. Uchimura, Y. Abe, R. Kawano, M. I. Konaklieva, M. Reimund, A. T. Remaley, Y. Sato, K.-i. Izutsu, H. Saito

This study shows that structural flexibility of A2-17 peptide enhances its ability to penetrate cell membranes compared to its constrained variants.

bioRxiv · Aug 16, 2023Biophysics

A Virus-like particle-based bivalent PCSK9 vaccine lowers LDL-cholesterol levels in Non-Human Primates

A. Fowler, K. K. A. Van Rompay, M. Sampson, J. Leo, J. K. Watanabe, J. L. Usachenko, R. Immareddy, D. M. Lovato, J. T. Schiller, A. T. Remaley, B. Chackerian

A bivalent PCSK9 vaccine using virus-like particles reduces LDL-cholesterol in non-human primates without statins, showing vaccine efficacy in cholesterol management.

bioRxiv · May 15, 2023Immunology

A VLP-based vaccine targeting ANGPTL3 lowers plasma triglycerides in mice

A. Fowler, M. Sampson, A. T. Remaley, B. Chackerian

This paper develops ANGPTL3-targeting VLP vaccines that lower plasma triglycerides in mice by enhancing lipoprotein lipase activity.

bioRxiv · Mar 8, 2021Immunology

Transgelin: A New Gene Involved in LDL Endocytosis Identified by a Genome-wide CRISPR-Cas9 Screen

D. Lucero, O. Dikilitas, M. M. Mendelson, P. Islam, E. B. Neufeld, A. T. Bansal, L. A. Freeman, B. Vaisman, J. Tang, C. A. Combs, Y. Li, S. Voros, I. J. Kullo, A. T. Remaley

This study identifies TAGLN as a new gene involved in LDL endocytosis through a CRISPR-Cas9 screen and shows its association with plasma lipid levels.

bioRxiv · Dec 23, 2020Cell Biology

Molecular basis for activation of lecithin:cholesterol acyltransferase by a compound that increases HDL cholesterol

K. A. Manthei, S.-M. Yang, B. Baljinnyam, L. Chang, A. Glukhova, W. Yuan, L. A. Freeman, D. J. Maloney, A. Schwendeman, A. T. Remaley, A. Jadhav, J. J. G. Tesmer

The paper reports the crystal structure of LCAT bound to an activator and inhibitor, showing how the activator stabilizes the MBD and enhances LCAT activity in FLD variants.

bioRxiv · Sep 20, 2018Biochemistry