Author

A. Schwendeman

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biochemistry· 1 Cancer Biology· 1 Immunology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Assay:bulk RNA-seq· 1 Research Focus:cancer & tumor microenvironment· 1 Research Focus:cell type annotation· 1 Research Focus:differential expression· 1 Organism:human· 1 Organism:mouse· 1 Research Focus:protein folding & dynamics· 1

Frequent Co-Authors

P. Kadiyala· 2 shared P. R. Lowenstein· 2 shared S. V. Carney· 2 shared Y. Liu· 2 shared A. Glukhova· 1 shared A. Jadhav· 1 shared A. Mujeeb· 1 shared A. T. Remaley· 1 shared

Activity by Year

2018-2022 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 21 mutual co-author links

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2 shared papersCancer Biology

P. Kadiyala

Mutual co-authors in cluster

Author profile →

3 papers

Recent·Most cited

Zinc Finger MYND-Type Containing 8 (ZMYND8) is epigenetically regulated in mutant Isocitrate Dehydrogenase 1 (IDH1) glioma to promote radioresistance

S. V. Carney, K. Banerjee, A. Mujeeb, B. Zhu, S. Haase, M. L. Varela, P. Kadiyala, C. Tronrud, Z. Zhu, D. Mukherji, P. Gorla, R. Tagett, F. J. Nunez, M. Luo, W. Lou, , M. G. Castro

This paper identifies ZMYND8 as a gene epigenetically regulated by mIDH1 that promotes radioresistance in glioma cells, and shows its knockdown enhances radiosensitivity.

bioRxiv · Jun 10, 2022Cancer Biology

Inhibition of 2-Hydroxyglutrate Elicits Metabolic-reprograming and Mutant IDH1 Glioma Immunity

P. Kadiyala, S. V. Carney, J. C. Gauss, M. Garcia-Fabiani, F. Nunez, F. M. Nunez, M. Alghamri, Y. Liu, M. Yu, D. Li, M. Edwards, J. J. Moon, A. Schwendeman, P. R. Lowenstein, M. Castro

This study shows that inhibiting 2-hydroxyglutarate in mIDH1 gliomas with ATRX/TP53 inactivation improves survival and induces anti-tumor immunity through immunological memory and reduced T-cell exhaustion.

bioRxiv · May 11, 2020 · PreprintImmunology

Molecular basis for activation of lecithin:cholesterol acyltransferase by a compound that increases HDL cholesterol

K. A. Manthei, S.-M. Yang, B. Baljinnyam, L. Chang, A. Glukhova, W. Yuan, L. A. Freeman, D. J. Maloney, A. Schwendeman, A. T. Remaley, A. Jadhav, J. J. G. Tesmer

The paper reports the crystal structure of LCAT bound to an activator and inhibitor, showing how the activator stabilizes the MBD and enhances LCAT activity in FLD variants.

bioRxiv · Sep 20, 2018Biochemistry