D. J. Maloney

Ameliorative effect of a quinazoline-based bromodomain inhibitor, CN210, on experimentally-induced Crohn's disease-like murine ileitis via inhibition of inflammatory cytokine expression

This study shows that CN210, a quinazoline-based BET inhibitor, reduces inflammation in a murine model of Crohn's disease by inhibiting inflammatory cytokine expression and NF-κB/MAP kinase pathways.

Molecular basis for activation of lecithin:cholesterol acyltransferase by a compound that increases HDL cholesterol

The paper reports the crystal structure of LCAT bound to an activator and inhibitor, showing how the activator stabilizes the MBD and enhances LCAT activity in FLD variants.