B. Baljinnyam

Application of Temperature-Responsive HIS-Tag Fluorophores to Differential Scanning Fluorimetry Screening of Small Molecule Libraries

The paper develops a high-throughput differential scanning fluorimetry assay using HIS-tag fluorophores to screen small molecule libraries for protein interactions.

Application of biophysical methods for improved protein production and characterization: a case study on an HtrA-family bacterial protease

This paper improves the production and characterization of HtrA-family proteins using optimized expression, refolding, and biophysical methods, resulting in pure, active proteins with monodisperse composition.

A real-time cellular thermal shift assay (RT-CETSA) to monitor target engagement

The paper introduces RT-CETSA, a real-time cellular thermal shift assay that improves throughput and sensitivity for monitoring ligand-target engagement in cells.

A hybrid in silico approach reveals novel inhibitors of multiple SARS-CoV-2 variants

The paper uses a hybrid in silico approach combining machine learning and pharmacophore modeling on NCATS screening data to identify novel inhibitors effective against multiple SARS-CoV-2 variants.

Real-time sharing of drug screening data on the NCATS OpenData Portal accelerates translational research

This paper describes the NCATS OpenData Portal, a platform for real-time sharing of drug screening data that accelerates translational research by enabling immediate access to large-scale datasets.

Molecular basis for activation of lecithin:cholesterol acyltransferase by a compound that increases HDL cholesterol

The paper reports the crystal structure of LCAT bound to an activator and inhibitor, showing how the activator stabilizes the MBD and enhances LCAT activity in FLD variants.

Discovery and optimization of piperazine-1-thiourea-based human phosphoglycerate dehydrogenase inhibitors

The paper develops a biochemical assay to screen for PHGDH inhibitors, identifies piperazine-1-thiourea compounds, and evaluates their biological impact on serine metabolism in cancer cells.