Author

L. A. Hehl

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biochemistry· 2

Signature Assays, Organisms & Methods

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Research Focus:cell signaling & trafficking· 2 Research Focus:chromatin & epigenetic regulation· 2 Approach:experimental assay· 2 Organism:human· 2 Research Focus:protein folding & dynamics· 2 Approach:biophysical modeling· 1 Assay:cryo-EM· 1 Assay:proteomics· 1

Frequent Co-Authors

B. A. Schulman· 2 shared J. R. Prabu· 2 shared A. F. Alpi· 1 shared C. R. Langlois· 1 shared D. A. Perez Berrocal· 1 shared D. Horn-Ghetko· 1 shared D. Sherpa· 1 shared D. T. Vu· 1 shared

Activity by Year

2021-2023 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 29 mutual co-author links

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2 shared papersBiochemistry

B. A. Schulman

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2 papers

Recent·Most cited

Structural snapshots along K48-linked ubiquitin chain formation by the HECT E3 UBR5

L. A. Hehl, D. Horn-Ghetko, J. R. Prabu, R. Vollrath, D. T. Vu, D. A. Perez Berrocal, M. P. C. Mulder, G. J. van der Heden van Noort, B. A. Schulman

This study uses cryo-EM to reveal the structural mechanism of K48-linked ubiquitin chain formation by the HECT E3 ligase UBR5, showing how it orchestrates ubiquitin transfer through conformational changes.

bioRxiv · Jun 6, 2023Biochemistry

GID E3 ligase supramolecular chelate assembly configures multipronged ubiquitin targeting of an oligomeric metabolic enzyme

D. Sherpa, J. Chrustowicz, S. Qiao, C. R. Langlois, L. A. Hehl, K. V. Gottemukkala, F. M. Hansen, O. Karayel, S. von Gronau, J. R. Prabu, M. Mann, A. F. Alpi, B. A. Schulman

The paper reveals a supramolecular chelate assembly mechanism by which E3 ligases target oligomeric substrates, demonstrating this in yeast and human orthologs.

bioRxiv · Apr 7, 2021Biochemistry