F. M. Hansen

Inhibition of mammalian mtDNA transcription paradoxically activates liver fatty acid oxidation to reverse diet-induced hepatosteatosis and obesity

The paper shows that inhibiting mitochondrial DNA transcription in mice increases fatty acid oxidation, reducing obesity and liver fat while decreasing oxidative phosphorylation capacity.

Rapid and in-depth coverage of the (phospho-)proteome with deep libraries and optimal window design for dia-PASEF

This paper introduces an optimized dia-PASEF method with variable isolation windows to enhance proteome and phosphoproteome coverage in mass spectrometry.

Mitochondrial phosphoproteomes are functionally specialized across tissues

The paper quantitatively profiles mitochondrial proteomes and phosphoproteomes across multiple tissues in mice, revealing tissue-specific kinase and phosphatase repertoires and functional phosphorylation events.

GID E3 ligase supramolecular chelate assembly configures multipronged ubiquitin targeting of an oligomeric metabolic enzyme

The paper reveals a supramolecular chelate assembly mechanism by which E3 ligases target oligomeric substrates, demonstrating this in yeast and human orthologs.

A new parallel high-pressure packing system enables rapid multiplexed production of capillary columns

A new parallel high-pressure packing system enables rapid multiplexed production of capillary columns, reducing production time by 40 to 800 times.

A regulatory interface on RIPK2 is required for XIAP binding and NOD signaling activity

The paper identifies a regulatory interface on RIPK2 essential for XIAP binding and NOD signaling by analyzing post-translational modifications in RIPK2 knock-in mice.