S. Qiao

Structure and evolution of Alanine/Serine Decarboxylases and the engineering of theanine production

This study solves the structures of AlaDC and SerDC, identifies key residues for activity and specificity, and shows engineered variants improve theanine production.

Epidemiological evaluation and identification of the insect vector of soybean stay-green associated virus

This study identifies SoSGV as the causative agent of soybean stay-green syndrome and confirms the common brown leafhopper as its vector, revealing its epidemiology and geographical spread.

Lipoprotein sorting to the cell surface via a crosstalk between the Lpt and Lol pathways during outer membrane biogenesis

The paper identifies lipoproteins transported to the cell surface via LptDE and reveals a crosstalk between Lpt and Lol pathways in Gram-negative bacteria.

Single-Cell RNA-seq of Heart Reveals Intercellular Communication Drivers of Myocardial Fibrosis in Diabetic Mice

This study uses single-cell RNA-seq to identify intercellular communication drivers of myocardial fibrosis in diabetic mice, highlighting key ligand-receptor interactions and fibroblast subpopulations involved in fibrosis.

Reduced sera neutralization to Omicron SARS-CoV-2 by bothinactivated and protein subunit vaccines and the convalescents

The paper tests neutralization activity of sera from convalescents and vaccine recipients against Omicron, finding that vaccines maintain better neutralization than convalescents.

A histidine cluster determines YY1-compartmentalized coactivators and chromatin elements in phase-separated super-enhancers

This study shows YY1 forms phase-separated super-enhancers by compartmentalizing coactivators and enhancer elements, with a histidine cluster essential for this process.

GID E3 ligase supramolecular chelate assembly configures multipronged ubiquitin targeting of an oligomeric metabolic enzyme

The paper reveals a supramolecular chelate assembly mechanism by which E3 ligases target oligomeric substrates, demonstrating this in yeast and human orthologs.

Leaf economics explained by optimality principles

The paper explains leaf economics using optimality principles, showing how leaf lifespan and LMA relate to environmental factors and resolving discrepancies in plant traits.

Bat and pangolin coronavirus spike glycoprotein structures provide insights into SARS-CoV-2 evolution

The paper determines cryo-EM structures of bat and pangolin coronavirus spikes, showing PCoV_GX spike binds human ACE2 like SARS-CoV-2, while RaTG13 does not, and identifies key residues and glycans involved in RBD function.

Cryo-EM structures of HKU2 and SADS-CoV spike glycoproteins and insights into coronavirus evolution

The paper reports cryo-EM structures of HKU2 and SADS-CoV spike glycoproteins, revealing structural similarities and evolutionary insights into coronavirus evolution.

Differential effects of Doxorubicin and Actinomycin D on the stability of RNA binding proteins, RBM10 and RBM5: Actinomycin D promotes the nuclear speckles targeting of RBM10 and RBM5 through the novel structural elements.

This study examines how Doxorubicin and Actinomycin D affect RBM10 and RBM5 protein stability and subnuclear localization, finding differential effects on their nuclear speckles targeting.

Enhancement of Macrophage Function by the Antimicrobial Peptide Sublancin Protects Mice from Methicillin-Resistant Staphylococcus aureus

This study shows that sublancin enhances macrophage function and protects mice from MRSA infection by activating innate immunity and improving T cell responses.