Author

R. Vollrath

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biochemistry· 3

Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Organism:human· 2 Research Focus:protein folding & dynamics· 2 Research Focus:cell signaling & trafficking· 1 Research Focus:cell type annotation· 1 Research Focus:chromatin & epigenetic regulation· 1 Assay:cryo-EM· 1 Research Focus:host-pathogen & immune response· 1

Frequent Co-Authors

B. A. Schulman· 3 shared J. R. Prabu· 3 shared C. R. R. Grace· 1 shared D. A. Perez Berrocal· 1 shared D. Haselbach· 1 shared D. Horn-Ghetko· 1 shared D. J. Miller· 1 shared D. L. Bolhuis· 1 shared

Activity by Year

2019-2023 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 30 mutual co-author links

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3 shared papersBiochemistry

B. A. Schulman

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Author profile →

3 papers

Recent·Most cited

Structural snapshots along K48-linked ubiquitin chain formation by the HECT E3 UBR5

L. A. Hehl, D. Horn-Ghetko, J. R. Prabu, R. Vollrath, D. T. Vu, D. A. Perez Berrocal, M. P. C. Mulder, G. J. van der Heden van Noort, B. A. Schulman

This study uses cryo-EM to reveal the structural mechanism of K48-linked ubiquitin chain formation by the HECT E3 ligase UBR5, showing how it orchestrates ubiquitin transfer through conformational changes.

bioRxiv · Jun 6, 2023Biochemistry

Insights into the ISG15 transfer cascade by the UBE1L activating enzyme

I. Wallace, K. Baek, J. R. Prabu, R. Vollrath, S. von Gronau, B. A. Schulman, K. N. Swatek

This study presents a cryo-EM structure of the UBE1L-UBE2L6 complex bound to ISG15, revealing mechanisms of ISG15 recognition and conjugation pathway specificity.

bioRxiv · Apr 6, 2023Biochemistry

A Protein Engineering Approach for Uncovering Cryptic Ubiquitin-binding Sites: from a Ubiquitin-Variant Inhibitor of APC/C to K48 Chain Binding

E. R. Watson, C. R. R. Grace, W. Zhang, D. J. Miller, I. F. Davidson, J. R. Prabu, S. Yu, D. L. Bolhuis, E. T. Kulko, R. Vollrath, D. Haselbach, H. Stark, J.-M. Peters, N. G. Brown, S. S. Sidhu, B. A. Schulman

The paper identifies a cryptic ubiquitin-binding site on APC/C using ubiquitin variants, revealing its preference for K48-linked chains and demonstrating a method for uncovering such sites in large complexes.

bioRxiv · Jun 12, 2019 · PreprintBiochemistry