Author

L. A. Hesser

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Bioengineering· 3 Microbiology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 4 Research Focus:host-pathogen & immune response· 4 Research Focus:drug response / drug discovery· 3 Organism:mouse· 3 Assay:metagenomics· 2 Assay:proteomics· 2 Research Focus:development & morphogenesis· 1 Organism:human· 1

Frequent Co-Authors

J. A. Hubbell· 3 shared S. Cao· 3 shared A. J. Slezak· 2 shared A. Solanki· 2 shared A. T. Alpar· 2 shared C. R. Nagler· 2 shared E. Campbell· 2 shared K. C. Refvik· 2 shared

Activity by Year

2022-2024 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 33 mutual co-author links

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3 shared papersBioengineering

J. A. Hubbell

Mutual co-authors in cluster

Author profile →

4 papers

Recent·Most cited

Engineered Flt3L Drives Tolerogenic State to Attenuate Anti-drug Antibody Responses

A. T. Alpar, R. P. Wallace, K. C. Refvik, S. Gomes, A. Solanki, L. T. Gray, A. J. Slezak, A. L. Lauterbach, L. A. Hesser, S. Cao, J. E. G. Medellin, L. G. Robinson, J. A. Hubbell

The paper describes a method using engineered Flt3L to induce a tolerogenic immune state, reducing anti-drug antibodies to a fungal enzyme.

bioRxiv · Mar 21, 2024 · PreprintBioengineering

Suppression of autoimmune arthritis and neuroinflammation via an amino acid-conjugatedbutyrate prodrug with enhanced oral bioavailability

S. Cao, E. Budina, M. M. Raczy, A. Solanki, M. Nguyen, T. N. Beckman, J. W. Reda, K. Hultgren, P. Ang, A. J. Slezak, L. A. Hesser, A. T. Alpar, K. C. Refvik, L. S. Shores, I. Pillai, , J. A. Hubbell

This study develops a butyrate prodrug, SerBut, which improves oral bioavailability and reduces autoimmune arthritis and neuroinflammation in mouse models.

bioRxiv · Apr 28, 2023 · PreprintBioengineering

TLR4 regulates proinflammatory intestinal immune responses mediated by an atopic gut microbiota

E. Campbell, L. Maccio-Maretto, L. A. Hesser, A. M. Kemter, R. B. Canani, R. Nocerino, L. Paparo, R. T. Patry, C. R. Nagler

The paper shows that a CMA-associated gut microbiota enriched in Bacteroidetes and LPS genes promotes proinflammatory responses via TLR4 signaling in infants with cows milk allergy.

bioRxiv · Jul 21, 2022 · PreprintMicrobiology

Microbial metabolite butyrate-prodrug polymeric micelles demonstrate therapeutic efficacy in pre-clinical models of food allergy and colitis

R. Wang, S. Cao, M. E. H. Bashir, L. A. Hesser, Y. Su, S. M. C. Hong, A. Thompson, E. Culleen, M. Sabados, N. P. Dylla, E. Campbell, R. Bao, E. B. Nonnecke, C. L. Bevins, D. S. Wilson, , C. R. Nagler

The paper develops butyrate-prodrug polymeric micelles that restore gut barrier function and reduce inflammation in pre-clinical models of food allergy and colitis.

bioRxiv · May 1, 2022Bioengineering