L. A. Hothorn

No observed effect concentration (NOEC) and minimal effective dose (MED): estimation of non-experimental doses

The paper estimates non-experimental doses using linear interpolation between experimental doses to maintain familywise error rate in bioassays.

Crystal structures of Arabidopsis and Physcomitrella CR4 reveal the molecular architecture of CRINKLY4 receptor kinases.

The paper reports crystal structures of CRINKLY4 receptor kinases from Arabidopsis and Physcomitrella, revealing their molecular architecture and functional domains.

Statistical analysis of no observed effect concentrations or levels in eco-toxicological assays with overdispersed count endpoints

The paper evaluates sixteen statistical tests for overdispersed count data in eco-toxicological assays and recommends a Dunnett-type procedure for its robust performance across various data conditions.

Inositol pyrophosphates promote the interaction of SPX domains with the coiled-coil motif of PHR transcription factors to regulate plant phosphate homeostasis.

The paper shows that InsP8 binds to SPX domains, altering PHR transcription factors' oligomeric state and DNA binding, thus regulating phosphate homeostasis in plants.

Statistical approach for ...a test chemical is considered to be positive... in regulatory toxicology: Trend and pairwise tests

The paper proposes two statistical approaches for determining positive outcomes in regulatory toxicology and provides related R software.

Pseudo-data generation allows the statistical re-evaluation of toxicological bioassays based on summary statistics

The paper generates pseudo-data to re-evaluate toxicological bioassays using summary statistics from published studies.

Two bifunctional inositol pyrophosphate kinases/phosphatases control plant phosphate homeostasis.

This study identifies VIH1 and VIH2 as bifunctional enzymes regulating phosphate homeostasis in Arabidopsis by modulating PP-InsP levels in response to ATP concentration changes.

Mechanistic analysis of the SERK3 elongated allele defines a role for BIR ectodomains in brassinosteroid signaling

The paper investigates the role of the SERK3 elongated allele in brassinosteroid signaling, finding that it disrupts BIR ectodomain interactions with co-receptors rather than enhancing BRI1 binding.