M. Hothorn

Inositol pyrophosphate catabolism by three families of phosphatases controls plant growth and development

This study identifies three phosphatase families involved in inositol pyrophosphate catabolism in plants, showing their roles in growth, development, and nutrient signaling.

Mechanistic insights into the function of 14-3-3 proteins as negative regulators of brassinosteroid signaling in Arabidopsis.

This study identifies 14-3-3 binding sites in BR signaling components and shows their role as negative regulators in Arabidopsis.

Phosphorylation and ubiquitination independent endocytosis of BRI1

This study shows that a BR-binding-deficient BRI1 mutant is internalized similarly to wild-type BRI1, suggesting parallel endocytic routes and non-canonical functions.

Structural and functional insight into the plant unique multimodular triphosphosphate tunnel metalloenzymes of Arabidopsis thaliana

This study characterizes the structural and functional properties of two multimodular triphosphosphate tunnel metalloenzymes in Arabidopsis thaliana, revealing their roles in developmental transitions.

Crystal structures of Arabidopsis and Physcomitrella CR4 reveal the molecular architecture of CRINKLY4 receptor kinases.

The paper reports crystal structures of CRINKLY4 receptor kinases from Arabidopsis and Physcomitrella, revealing their molecular architecture and functional domains.

A constitutively monomeric UVR8 photoreceptor allele confers enhanced UV-B photomorphogenesis

The paper describes a hyperactive UVR8 allele that causes constitutive photomorphogenesis and enhanced UV-B responsiveness due to impaired dimerization and inactivation.

Constitutive activation of leucine-rich repeat receptor kinase signaling pathways by BAK1-interacting receptor-like kinase 3 chimera

The paper reports that chimeric receptor proteins formed by fusing BIR3 LRR domains with SERK-dependent LRR-RK kinase domains activate signaling pathways constitutively, leading to gain-of-function phenotypes.

Inositol pyrophosphates promote the interaction of SPX domains with the coiled-coil motif of PHR transcription factors to regulate plant phosphate homeostasis.

The paper shows that InsP8 binds to SPX domains, altering PHR transcription factors' oligomeric state and DNA binding, thus regulating phosphate homeostasis in plants.

A two-way molecular dialogue between embryo and endosperm required for seed development

The paper identifies a bidirectional molecular dialogue between embryo and endosperm involving TWS1 and ALE1 to ensure cuticle integrity during seed development.

Molecular mechanism for the recognition of sequence-divergent CIF peptides by the plant receptor kinases GSO1/SGN3 and GSO2.

This paper identifies the molecular mechanism by which plant receptor kinases GSO1/SGN3 and GSO2 recognize sequence-divergent CIF peptides through structural and biochemical analyses.

A genetically validated approach to detect inorganic polyphosphates in plants.

The paper develops a method to detect inorganic polyphosphates in plants using a dye and binding domain, finding that higher plants lack large polyP stores.

Crystal structure of the LRR ectodomain of the plant immune receptor kinase SOBIR1.

The paper reports the crystal structure of the LRR ectodomain of the plant immune receptor kinase SOBIR1, revealing unique capping domains and potential protein-protein interaction sites.

Plant photoreceptors and their signaling components compete for binding to the ubiquitin ligase COP1 using their VP-peptide motifs

The paper shows that photoreceptors and transcription factors compete for COP1 binding via VP-peptide motifs, controlling light signaling in plants.

Molecular characterization of CHAD domains as inorganic polyphosphate binding modules

This study identifies CHAD domains as specific inorganic polyphosphate binding modules across bacteria, archaea, and eukaryotes, revealing their structural and functional roles in polyP metabolism and localization.

Mechanistic insights into the evolution of DUF26-containing proteins in land plants

The paper traces the evolutionary history of DUF26-containing proteins in land plants, showing their origin from secreted proteins and expansion through duplication mechanisms.

Two bifunctional inositol pyrophosphate kinases/phosphatases control plant phosphate homeostasis.

This study identifies VIH1 and VIH2 as bifunctional enzymes regulating phosphate homeostasis in Arabidopsis by modulating PP-InsP levels in response to ATP concentration changes.

Mechanistic analysis of the SERK3 elongated allele defines a role for BIR ectodomains in brassinosteroid signaling

The paper investigates the role of the SERK3 elongated allele in brassinosteroid signaling, finding that it disrupts BIR ectodomain interactions with co-receptors rather than enhancing BRI1 binding.