D. Fiedler

Inositol pyrophosphate catabolism by three families of phosphatases controls plant growth and development

This study identifies three phosphatase families involved in inositol pyrophosphate catabolism in plants, showing their roles in growth, development, and nutrient signaling.

An uncommon phosphorylation mode regulates the activity and protein-interactions of N-acetylglucosamine kinase

This study investigates the regulatory role of pyrophosphorylation on NAGK activity and protein interactions, revealing its impact on kinase function and stability.

An unconventional gatekeeper mutation sensitizes inositol hexakisphosphate kinases to an allosteric inhibitor

The paper identifies FMP-201300 as a potent and selective inhibitor for IP6K1 and IP6K2 with a valine gatekeeper mutation, revealing an allosteric mechanism of action.

Pyrophosphoproteomics: extensive protein pyrophosphorylation revealed in human cell lines

This study identifies endogenous protein pyrophosphorylation in human cell lines using a tailored pyrophosphoproteomics workflow, revealing its role in rDNA transcription regulation.

Stable isotopomers of myo-inositol to uncover the complex MINPP1-dependent inositol phosphate network

The paper uses stable isotopomers of myo-inositol to analyze the MINPP1-dependent inositol phosphate network in human cells, revealing a novel dephosphorylation branch.

Inositol pyrophosphate-controlled kinetochore architecture and mitotic entry in S. pombe

This study shows that IP8, regulated by Asp1, controls kinetochore architecture and mitotic entry in S. pombe by modulating spindle dynamics and chromosome segregation fidelity.

Arabidopsis PFA-DSP-type phosphohydrolases target specific inositol pyrophosphate messengers

This study identifies Arabidopsis PFA-DSP proteins as specific inositol pyrophosphate phosphohydrolases, revealing their role in regulating these signaling molecules.

Analysis of Inositol Phosphate Metabolism by Capillary Electrophoresis Electrospray Ionization Mass Spectrometry (CE-ESI-MS)

This paper develops a CE-ESI-MS method to analyze inositol phosphates and pyrophosphates, revealing unknown synthesis pathways in mammals.

ITPK1 is an InsP6/ADP phosphotransferase that controls systemic phosphate homeostasis in Arabidopsis

This study shows ITPK1 generates PP-InsPs from InsP6 and regulates phosphate homeostasis in Arabidopsis by controlling InsP7 and InsP8 synthesis.

Protein Targets of Inositol Pyrophosphate (5-IP7) in the parasite Trypanosoma cruzi

This study identifies 5-IP7 protein targets in Trypanosoma cruzi using affinity pull-down and mass spectrometry, revealing distinct target profiles in different proliferative stages and potential therapeutic targets.

Inositol pyrophosphates promote the interaction of SPX domains with the coiled-coil motif of PHR transcription factors to regulate plant phosphate homeostasis.

The paper shows that InsP8 binds to SPX domains, altering PHR transcription factors' oligomeric state and DNA binding, thus regulating phosphate homeostasis in plants.

Two bifunctional inositol pyrophosphate kinases/phosphatases control plant phosphate homeostasis.

This study identifies VIH1 and VIH2 as bifunctional enzymes regulating phosphate homeostasis in Arabidopsis by modulating PP-InsP levels in response to ATP concentration changes.