S. Okuda

qMaLioffG: A single green fluorescent protein FLIM indicator enabling quantitative imaging of endogenous ATP

The paper introduces qMaLioffG, a green fluorescent protein FLIM indicator that quantitatively measures endogenous ATP levels by detecting fluorescence lifetime changes in physiological ATP concentrations.

Modelling contractile ring formation and division to daughter cells for simulating proliferative multicellular dynamics

This study introduces a model to simulate subcellular-level cell proliferation dynamics, including contractile ring formation and division, and shows it replicates tissue-scale multicellular behavior.

Multicellular dynamics on structured surfaces: Stress concentration is a key to controlling complex microtissue morphology on engineered scaffolds

This study identifies stress concentration as a key factor in microtissue detachment from engineered scaffolds and develops a computational model to predict and control this process.

Isoform-specific mutation in Dystonin-b gene causes late-onset protein aggregate myopathy and cardiomyopathy

This study identifies a Dst-b mutation causing late-onset myopathy and cardiomyopathy in mice, revealing its critical role in striated muscle maintenance.

Crystal structures of Arabidopsis and Physcomitrella CR4 reveal the molecular architecture of CRINKLY4 receptor kinases.

The paper reports crystal structures of CRINKLY4 receptor kinases from Arabidopsis and Physcomitrella, revealing their molecular architecture and functional domains.

Marcksl1 modulates endothelial cell mechanoresponse to haemodynamic forces to control blood vessel shape and size

This study shows that Marcksl1 modulates endothelial cell mechanical responses to blood flow, affecting vessel size and shape during angiogenesis.

Three-dimensional understanding of the morphological complexity of the human uterine endometrium

This study uses 3D imaging to reveal the complex morphology of human endometrial glands and their pathological features in adenomyosis.

A two-way molecular dialogue between embryo and endosperm required for seed development

The paper identifies a bidirectional molecular dialogue between embryo and endosperm involving TWS1 and ALE1 to ensure cuticle integrity during seed development.

Molecular mechanism for the recognition of sequence-divergent CIF peptides by the plant receptor kinases GSO1/SGN3 and GSO2.

This paper identifies the molecular mechanism by which plant receptor kinases GSO1/SGN3 and GSO2 recognize sequence-divergent CIF peptides through structural and biochemical analyses.

Cryo-EM structure of the human L-type amino acid transporter 1 in complex with glycoprotein CD98hc

This paper reports the cryo-EM structure of the human LAT1-CD98hc heterodimer, revealing its architecture and interactions, and maps disease mutations to explain congenital disorders.