Author

L. A. McDonnell

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cancer Biology· 2

Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Organism:human· 2 Assay:bulk RNA-seq· 1 Research Focus:cell signaling & trafficking· 1 Research Focus:drug response / drug discovery· 1 Assay:metabolomics· 1 Assay:proteomics· 1

Frequent Co-Authors

A. Botto· 1 shared A. Gregori· 1 shared A. J. M. Zweemer· 1 shared A. Mukherjee· 1 shared B. van de Water· 1 shared C. Bergonzini· 1 shared C.-Y. Chiang· 1 shared D. Bezwada· 1 shared

Activity by Year

2022-2023 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 21 mutual co-author links

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1 shared paperCancer Biology

A. Botto

Mutual co-authors in cluster

Author profile →

2 papers

Recent·Most cited

ABCB1 overexpression through locus amplification represents an actionable target to combat paclitaxel resistance in pancreatic cancer cells

C. Bergonzini, A. Gregori, T. M. S. Hagens, V. E. van der Noord, B. van de Water, A. J. M. Zweemer, M. Capula, G. Mantini, A. Botto, F. Finamore, I. Garajova, L. A. McDonnell, T. Schmidt, E. Giovannetti, E. H. J. Danen

This study identifies ABCB1 overexpression via locus amplification as a conserved mechanism of paclitaxel resistance in PDAC and shows that targeting ABCB1 can sensitize resistant cells to treatment.

bioRxiv · May 30, 2023 · PreprintCancer Biology

Adipocytes reprogram glucose metabolism in cancer cells promoting metastasis

A. Mukherjee, D. Bezwada, M. Zandbergen, F. Francesco Greco, C.-Y. Chiang, M. Tasdemir, J. Fahrmann, D. Grapov, M. R. La Frano, H. S. Vu, J. W. Newman, L. A. McDonnell, L. Nezi, O. Fiehn, R. J. DeBerardinis, E. Lengyel

This study shows adipocytes reprogram cancer cell glucose metabolism to promote metastasis by increasing lipid synthesis via HIF1 regulation.

bioRxiv · Oct 17, 2022 · PreprintCancer Biology