Author

H. S. Vu

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biochemistry· 3 Cancer Biology· 2

Signature Assays, Organisms & Methods

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Approach:experimental assay· 5 Organism:human· 5 Assay:metabolomics· 5 Research Focus:cell signaling & trafficking· 2 Research Focus:metabolism & bioenergetics· 2 Research Focus:cancer & tumor microenvironment· 1 Assay:proteomics· 1

Frequent Co-Authors

R. J. DeBerardinis· 5 shared D. Bezwada· 3 shared D. Do· 3 shared F. Cai· 3 shared L. Cai· 3 shared S. Kelekar· 3 shared Z. Wu· 3 shared B. Brooks· 2 shared

Activity by Year

2021-2023 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 43 mutual co-author links

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5 shared papersBiochemistry

R. J. DeBerardinis

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Author profile →

5 papers

Recent·Most cited

Electron transport inhibition increases cellular dependence on purine transport and salvage

Z. Wu, D. Bezwada, R. C. Harris, C. Pan, P. T. Nguyen, B. Faubert, L. Cai, F. Cai, H. S. Vu, H. Chen, M. Martin-Sandoval, D. Do, W. Gu, Y. Zhang, B. Ko, , R. J. DeBerardinis

This study shows that ETC inhibition in cancer cells increases reliance on purine salvage and transport, revealing a metabolic vulnerability in tumors with low oxidative metabolism.

bioRxiv · May 11, 2023Biochemistry

Mitochondrial metabolism in primary and metastatic human kidney cancers

D. Bezwada, R. J. DeBerardinis, N. P. Lesner, B. Brooks, H. S. Vu, Z. Wu, L. Cai, S. Kasitinon, S. Kelekar, F. Cai, A. B. Aurora, M. Patrick, A. Leach, R. Ghandour, Y. Zhang, , V. Margulis

This study investigates mitochondrial metabolism in kidney cancers, finding that primary tumors have suppressed mitochondrial function while metastases show enhanced TCA cycle labeling.

bioRxiv · Feb 6, 2023Cancer Biology

Adipocytes reprogram glucose metabolism in cancer cells promoting metastasis

A. Mukherjee, D. Bezwada, M. Zandbergen, F. Francesco Greco, C.-Y. Chiang, M. Tasdemir, J. Fahrmann, D. Grapov, M. R. La Frano, H. S. Vu, J. W. Newman, L. A. McDonnell, L. Nezi, O. Fiehn, R. J. DeBerardinis, E. Lengyel

This study shows adipocytes reprogram cancer cell glucose metabolism to promote metastasis by increasing lipid synthesis via HIF1 regulation.

bioRxiv · Oct 17, 2022 · PreprintCancer Biology

Comprehensive isotopomer analysis of glutamate and aspartate in small tissue samples

F. Cai, D. J. Bezwada, L. Cai, R. Mahar, Z. Wu, P. Pachnis, C. Yang, S. Kelekar, W. Gu, H. S. Vu, T. P. Mathews, L. G. Zacharias, M. Martin-Sandoval, D. Do, K. C. Oaxaca, , R. J. DeBerardinis

This paper develops an MS method to analyze all 16 aspartate and 32 glutamate isotopomers with high sensitivity, enabling pathway discrimination and metabolic heterogeneity studies in human tumors.

bioRxiv · Jul 31, 2022Biochemistry

The anti-angiogenic compound dimethyl fumarate inhibits the serine synthesis pathway and increases glycolysis in endothelial cells

M. C. Ocana, C. Yang, M. Bernal, B. Martinez-Poveda, H. S. Vu, C. Cardenas, R. J. DeBerardinis, A. R. Quesada, M. A. Medina

This study shows dimethyl fumarate inhibits serine synthesis and increases glycolysis in endothelial cells, potentially explaining its anti-angiogenic effects.

bioRxiv · Dec 13, 2021 · PreprintBiochemistry