O. Fiehn

Adipocytes reprogram glucose metabolism in cancer cells promoting metastasis

This study shows adipocytes reprogram cancer cell glucose metabolism to promote metastasis by increasing lipid synthesis via HIF1 regulation.

The metabolite alpha-ketobutyrate increases health and life spans by activating AMPK

This paper shows that alpha-ketobutyrate extends lifespan and healthspan in C. elegans and mice by activating AMPK through MACF1/VAB-10.

Profiling of the human intestinal microbiome and bile acids under physiologic conditions using an ingestible sampling device

The paper develops an ingestible device to collect intestinal samples and identifies regional differences in microbiota and bile acids compared to stool.

Metabolite Damage and Damage-Control in a Minimal Genome

The paper identifies and validates genes involved in metabolite damage repair and preemption in the minimized Mycoplasma JCVI-Syn3A genome and extends its metabolic map.

Metabolomics of lung microdissections reveals region- and sex-specific metabolic effects of acute naphthalene exposure in mice

This study uses metabolomics to show that acute naphthalene exposure causes region- and sex-specific metabolic changes in mouse lungs.

Diet High in Soybean Oil Increases Susceptibility to Colitis in Mice

This study shows that a soybean oil-rich diet increases colitis susceptibility in mice by altering HNF4, gut microbiota, and metabolites.

An adaptive teosinte mexicana introgression modulates phosphatidylcholine levels and is associated with maize flowering time

This study identifies an introgression from teosinte mexicana that affects HPC1, modulating phosphatidylcholine levels and influencing maize flowering time under low-temperature conditions.

Thioproline formation as a driver of formaldehyde toxicity in Escherichia coli

This study identifies thioproline formation as a key contributor to formaldehyde toxicity in E. coli and suggests PepP as a potential damage-control enzyme.

Cervicovaginal microbiome composition drives metabolic profiles in healthy pregnancy

The paper investigates how cervicovaginal microbiome composition influences metabolic profiles in healthy pregnancies across trimesters and the first year of life.

The circulating lipidome is largely defined by sex descriptors in the GOLDN, GeneBank and the ADNI studies

The paper examines sex differences in the blood lipidome across three cohorts, finding that 60% of lipids differ between men and women, with distinct lipid class distributions.

NAD(P)HX repair deficiency causes central metabolic perturbations in yeast and human cells

This study shows that NAD(P)HX repair deficiency in yeast and human cells causes metabolic perturbations, including NADHX accumulation, NAD+ depletion, and impaired mitochondrial function.